Organosulfur Compounds
Medchemexpress LLC Fast garnet GBC sulfate salt | 101-89-3 | MFCD00011883 | 90.0% | 334.35 g/mol | C14H14N4O4S | 50 MG
Fast garnet GBC sulfate salt, 90% is an azo diazonium dye used as a chromogenic substrate for alkaline phosphatase in histochemical staining and related enzymatic assays. It is supplied as a sulfate salt with high dye content suitable for laboratory staining protocols.
- Chromogenic substrate for alkaline phosphatase staining
- High dye content, formulated at 90.0% purity
- Suitable for histochemistry and enzyme activity assays
- Available in small laboratory-scale quantities
- Solid form with molecular formula C14H14N4O4S
TARGETMOL CHEMICALS INC GPR40/FFAR1 MODULATOR 1 5MG
Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator. purity: 99%
Medchemexpress LLC N'-(3-acetylphenyl)-N-(3-(2-methoxyethyl)-2,4-dioxo-1-(2-(piperidin-1-yl)ethyl)-1,2,3,4-tetrahydroquinazolin | 2946701-09-1 | 99.3% | 507.58 g/mol | C27H33N5O5 | 10 MG
COP1-ATGL modulator 1 is an orally active small-molecule research reagent that modulates the COP1-ATGL pathway. It increases ATGL protein expression, reduces ATGL and COP1 ubiquitination, and diminishes lipid accumulation in hepatocytes at nanomolar concentrations. Supplied as a white to off-white solid with high purity and defined storage recommendations for powder and solution.
- Orally active modulator of COP1-ATGL signaling.
- Increases ATGL protein expression at nanomolar concentrations.
- Reduces ATGL and COP1 ubiquitination in cellular assays.
- High purity suitable for research applications.
- Stable solid with recommended low-temperature storage.
Medchemexpress LLC CXCR7 modulator 2 | 2227426-37-9 | 98.71% | 522.68 | 1 ML
CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM. It is for research use only and not sold to patients. This modulator offers protection against cardiac injury.
- Potent CXCR7-binding affinity (Ki=13 nM).
- β-arrestin activity (EC50=11 nM).
- Improved selectivity in the GPCR panel.
- Improved therapeutic index in the hERG patch-clamp assay.
- Moderate to high in vitro turnover in NADPH-supplemented mouse-liver microsomes (MLM, 93 μL/min/mg) and hepatocytes (28 μL/min per million cells).
- Good aqueous solubility.
- Rapidly absorbed with a mean maximal plasma concentration (Cmax) of 682 ng/mL at 0.25 h (Tmax).
- Reduces cardiac fibrosis in an isoproterenol-induced cardiac injury model in mice.
Medchemexpress LLC Elafibranor sulfoxide | 95.0% | 400.49 | C22H24O5S | 10 MG
Elafibranor sulfoxide is the sulfoxide metabolite of elafibranor supplied as a research-grade powder for in vitro and preclinical studies. It is intended for laboratory research use only and can be used to investigate PPAR-related pathways and metabolic disease models such as primary biliary cholangitis.
- Chemical formula C22H24O5S, molecular weight 400.49.
- Supplied as a powder; pack sizes include 10 MG.
- Purity (NMR): 95.0%.
- Target: PPAR; drug metabolite.
- Storage: powder -20°C for 3 years, 4°C for 2 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Provided for research use only; not for human therapeutic use.
Medchemexpress LLC GLP-1R modulator L7-028 | 2648317-95-5 | 99.47% | C24H28N2O3 | 100 MG
GLP-1R modulator L7-028 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site (EC50 11.01 ± 2.73 μM). It is intended for research use only.
- Available as a solid, white to off-white in color.
- Soluble in DMSO at 100 mg/mL.
- Shipped at room temperature in continental US.
Medchemexpress LLC Mutant p53 modulator-1 | 2746371-35-5 | 99.89% | C27H32F4N8O2 | 100 MG
Mutant p53 modulator-1 is a compound that modulates mutant p53. It has been shown to reduce the progression of various cancers characterized by p53 mutations.
- Functions as a modulator for mutant p53.
- Aids in reducing the progression of cancers with p53 mutations.
- Available in both solid and solution forms for research applications.
Medchemexpress LLC GLP-1R modulator L7-028 | 2648317-95-5 | 99.5% | C24H28N2O3 | 25 MG
GLP-1R modulator L7-028 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site (EC50 11.01 ± 2.73 μM).
- Enhances GLP-1 binding to GLP-1R
- Functions as an allosteric modulator
- Acts via a transmembrane site
- Molecular weight: 392.49
- Appearance: solid, white to off-white
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In-solvent storage: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO: 100 mg/mL (254.78 mM)
Medchemexpress LLC Sulforaphane | 4478-93-7 | 99.75% | 177.29 | 200 MG
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. It promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. It protects the heart through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission and exhibits both anticancer and anti-inflammatory properties.
- Targets: HDAC, Keap1-Nrf2, Apoptosis, Bcl-2 family, Caspase, Reactive oxygen species (ROS)
- Research areas: Inflammation/Immunology, Cancer
Cayman Chemical GlycerophosphoNPalmitoyl Etha
Precursor of PEA, an endogenous CB found in brain, liver, and other mammalian tissues; PEA has potent anti-inflammatory activity in vivo